Opaleye Management Inc

10% owner Opaleye Management acquires 7,685 shares over 3 days (June 11–15) at $5.96 avg; company unprofitable, stock down 48.1% from 52-week high.

Opaleye Management, a 10% shareholder in unprofitable ACOG, executed 3 separate purchases totaling 7,685 shares for $45,773.11 over a narrow four-day window from June 11–15, 2026, at a blended average price of $5.96. This accumulation occurs within a challenging valuation context: the company posted $-6,478,018.00 in net income on $3,533,798.00 quarterly revenue, and the stock trades at $5.99 today, 48.1% below its 52-week high of $11.54. Notably, Opaleye's prior 5 trades at ACOG (all buys on May 20–29) were each well-timed at the 90-day mark, with returns ranging from +2.0% to +5.6%, establishing a consistent pattern of entry execution at this ticker. The timing of this latest purchase cluster shortly after those successful May positions, combined with the continued accumulation despite material losses in the latest quarter, warrants attention to whether management commentary or operational developments informed this insider activity.

Opaleye Management (10% owner) purchases 30,728 shares in ACOG for $183,691.91; stock up 10% in 30 days despite -47.7% from 52-week high.

Opaleye Management acquired 30,728 shares across two separate transactions for $183,691.91 at an average price of $5.98, increasing holdings by 1.2% to 2,644,889 shares. This accumulation occurs while the stock trades 47.7% below its 52-week high of $11.54, though it has gained 10% over the prior 30 days. Notably, Opaleye's prior 5 purchases at ACOG were all well-timed, with positive 90-day returns ranging from 2.0% to 5.6%, establishing a consistent pattern of favorable entry points at this ticker. Against this backdrop, the company remains unprofitable with net income of $-6,478,018.00 over its most recent full fiscal year and quarterly revenue of only $3,533,798.00, leaving limited fundamental support for the stock's valuation despite the 10% near-term recovery.

10% owner Opaleye Management buys 10,054 shares of ACOG at $5.83; stock down 48.0% from 52-week high but insider has 5 consecutive buy-side wins at this ticker.

Opaleye Management, a 10% shareholder, purchased 10,054 shares at $5.83 on 2026-06-05, expanding its position to 2,614,161 shares. The transaction occurs with Alpha Cognition trading at $6.00, down 48.0% from its 52-week high of $11.54, despite the company reporting net income of $-6,478,018.00 for its most recent period. Notably, all 5 prior purchases by this insider at ACOG showed positive 90-day returns, ranging from +2.0% to +5.6%, establishing a 100.00% well-timed rate at the 90-day mark on this ticker. The cross-ticker track record shows 16 prior buys with an average 90-day return of +11.4%, providing broader context for the insider's historical buy-side timing, though this ticker-specific pattern at ACOG represents the most directly comparable precedent.

Opaleye Management buys 73,738 shares for $434,713.77 at $5.90 avg; 10% holder now holds 2,604,107 shares

Opaleye Management Inc, a 10% owner, executed 3 separate purchases totaling 73,738 shares for $434,713.77 between May 27–29, 2026, at a blended average price of $5.90. The current price of $6.19 sits -46.4% from the 52-week high of $11.54, within the 52-week range of $4.50–$11.54. Opaleye's track record across all tickers shows 16 prior open-market buys with an average 90-day return of +8.3% and a 90-day win rate of 100.00%, while at ACOG specifically, all 5 prior buys (most recent on 2026-05-21, 2026-05-20, 2026-05-18, 2026-05-15, and 2026-03-30) were well-timed at the 90-day mark. However, the company reported negative net income of $-6,478,018.00 in its latest quarter and was unprofitable over its most recent full fiscal year, which provides material context for evaluating the investment signal embedded in this accumulation.

10% owner Opaleye Management buys 24,376 shares in 2 transactions for $140,545.09; stock down 49.3% from 52-week high.

Opaleye Management, a 10% shareholder, acquired 24,376 shares across two separate purchases on 2026-05-20 and 2026-05-21 at blended average price $5.77, bringing holdings to 2,530,369 shares post-transaction. This accumulation occurs while the stock trades -49.3% from its 52-week high of $11.54 and has declined 16.3% over the prior 30 days. At ACOG specifically, Opaleye's 5 prior trades show a timing pattern where 4 of 5 buys achieved positive 90-day returns, including three consecutive March purchases returning +17.7%, +35.0%, and +29.7% at the 90-day mark. Against this backdrop, the company remains unprofitable with net income of $-6,478,018.00 against quarterly revenue of $3,533,798.00. The filing provides raw transaction and position data; investors should assess whether the insider's historical accuracy at this ticker and the magnitude of accumulated shares signal continued conviction or reflect other factors in a loss-making business.

10% owner Opaleye bought 1,563 shares of SLGL at $64.43; stock now $76.73, up 4.4% in 30 days

Opaleye Management, holding 490.0K shares post-transaction, purchased 1,563 shares at $64.43 on 2026-05-20, a modest addition representing +0.3% vs pre-transaction holdings. The current price of $76.73 reflects a 30-day gain of +4.4% since the transaction, though the stock remains -21.7% from its 52-week high of $97.97. Within SLGL specifically, Opaleye's prior 4 trades show mixed outcomes: 2 of 4 prior buys were well-timed at the 90-day mark, though recent purchases on 2026-05-13 and 2026-05-12 posted only +2.2% and +0.5% 90-day returns respectively. Across all tickers, the insider's track record shows stronger execution (16 prior buys averaging +12.7% 30-day return, 75% 90-day win rate), but SLGL-specific timing has been inconsistent, warranting observation of whether this incremental purchase pattern continues or intensifies.

Opaleye Management Inc (10% owner) buys 34,043 shares at $5.76 avg; prior 5 ACOG trades all 90d positive, now at 52-week low -49.7%

Opaleye Management Inc executed 2 separate purchases totaling 34,043 shares for $196,009.03, adding 1.4% to a 2.51M-share position. The stock trades at -49.7% from its 52-week high of $11.54 and is down -16.4% over the past 30 days, despite a +0.0% 90-day change. Notably, this insider's prior 5 purchases at ACOG (March 24–30, 2026) all showed positive 90-day returns ranging from +6.4% to +19.3%, establishing a pattern of well-timed entry at this ticker. The current purchases occur at prices ($5.83 and $5.69) near the lower end of the 52-week range ($4.50–$11.54), following a sharp recent decline. However, the company remains unprofitable (net income $-6,478,018.00 for the most recent period) with a market cap of $126,289,803.20, adding material context to the timing and scale of this accumulation.

10% owner Opaleye Management adds 3,437 shares at SLGL, bringing stake to 488.4K shares amid -29.9% drawdown from 52-week high

Opaleye Management Inc, a 10% beneficial owner of Sol-Gel Technologies, purchased 3,437 shares totaling $231,502.33 on 2026-05-12, increasing its stake to 488,437 shares post-transaction. This accumulation occurs at a notably depressed valuation: the stock is trading at -29.9% from its 52-week high of $97.97 and down -10.2% over the prior 30 days, suggesting the insider is deploying capital into a weakness. The insider's historical track record shows 16 prior buys with an average 30-day return of +13.9% and a 90-day win rate of 100.00%, establishing a demonstrated pattern of bullish conviction on entry timing. Given Opaleye's substantial 10% ownership position and its track record of value-oriented purchases, this incremental buy into depressed prices warrants investor attention as a potential signal of conviction in Sol-Gel's recovery potential.

10% owner Opaleye Management sells ~71K shares across two days as SNWV stock slides from recent highs

Opaleye Management, a substantial institutional holder owning more than 10% of SANUWAVE, executed a multi-day sale totaling approximately $1.3 million in shares on April 28-29. The timing is notable: the stock has fallen significantly from its recent highs and is now trading well below where it was trading even thirty and ninety days ago, suggesting this liquidation came during a period of downward momentum. However, this transaction reflects routine portfolio rebalancing by an investment fund, not insider knowledge—Opaleye holds no operational role at the company. The company itself remains profitable with strong revenue growth and a reasonable valuation, so the fund's sale appears driven by portfolio management considerations rather than a loss of confidence in the business fundamentals. For investors, this filing is mostly administrative in nature and should not be interpreted as an executive abandoning ship.

Opaleye Management (10% owner) purchases 11,850 shares across 2 transactions for $60,018.51 at $5.06 average amid -51.2% decline from 52-week high.

Opaleye Management executed 2 separate purchases totaling 11,850 shares for $60,018.51 at a blended average price of $5.06, increasing its holding to 2,471,850 shares. The timing coincides with significant recent price weakness: the stock is -51.2% from its 52-week high of $11.24 and down 8.5% over the past 30 days. Alpha Cognition remains unprofitable with negative net income of $-1,318,074.00 in its latest quarter. Opaleye's prior trades at this ticker are all recent buys (5 consecutive buys from 2026-03-18 through 2026-03-26), but their 90-day outcomes remain immeasurable; across the insider's broader cross-ticker track record, 16 prior buys vs 4 prior sells suggests a historical bias toward accumulation, though this context does not speak to timing accuracy at this particular security.