SLGL Sol-Gel Technologies Ltd. Insider Trading

Opaleye Management Inc (10% owner) purchases 1,695 shares at SLGL for $124,818.63 in two transactions on 2026-07-13 and 2026-07-14.

Opaleye Management Inc, holding 493.9K shares (10% owner), executed 2 purchases totaling 1,695 shares for $124,818.63 at blended average price $73.64. The current price of $77.22 is -21.2% from the 52-week high of $97.97, placing the stock in a drawdown from its recent peak. At SLGL specifically, Opaleye has now completed two prior buys on 2026-07-01 and 2026-07-02, followed by these purchases on 2026-07-13 and 2026-07-14; outcomes from those earlier trades are not yet measurable. Across the insider's broader open-market history, 15 prior buys averaged +24.2% return at the 30-day mark, though the timing record at this specific ticker remains incomplete for assessment.

Opaleye Management (10% owner) bought 529 shares of SLGL for $39,041.55 across 2 purchases at $73.69–$73.95 on 2026-07-08 and 2026-07-10.

Opaleye Management executed 2 separate purchases totaling 529 shares for $39,041.55 at an blended average price of $73.80, a level that sits -24.5% from the 52-week high of $97.97 and only +0.6% above the 30-day average, suggesting acquisition near recent near-term equilibrium rather than at capitulation levels. The 10% owner's holdings increased modestly from 491,712 shares to 492,241 shares (+0.1%), a marginal addition to an already substantial position in a $206.0M market-cap company. Opaleye's cross-ticker track record shows 15 prior buys with an average 30-day return of +24.2%, though same-ticker history at SLGL consists of only 2 prior buy transactions (both 2026-07-01 and 2026-07-02, outcomes not yet measurable), offering limited insight into the insider's timing pattern at this specific holding.

10% Owner Opaleye Management buys 1,712 shares at $71.97 avg across 2 purchases for $123.2K

Opaleye Management Inc, a 10% shareholder of Sol-Gel Technologies, completed 2 separate purchases totaling 1,712 shares for $123,219.86 on July 1-2, 2026, at a blended average price of $71.97. The current price of $74.01 stands -24.5% from the 52-week high of $97.97, and this acquisition increases Opaleye's holdings from 490,000 shares to 491,712 shares (+0.3%). Notably, Opaleye's prior three purchases at SLGL across May 2026 all showed positive 30-day returns (+15.6%, +9.8%, +10.8%), though 90-day outcomes remain unmeasurable. The insider's cross-ticker buy track record shows 16 prior purchases with an average 30-day return of +13.0%, providing context for a pattern of historically favorable near-term performance after open-market purchases.

10% owner Opaleye bought 1,563 shares of SLGL at $64.43; stock now $76.73, up 4.4% in 30 days

Opaleye Management, holding 490.0K shares post-transaction, purchased 1,563 shares at $64.43 on 2026-05-20, a modest addition representing +0.3% vs pre-transaction holdings. The current price of $76.73 reflects a 30-day gain of +4.4% since the transaction, though the stock remains -21.7% from its 52-week high of $97.97. Within SLGL specifically, Opaleye's prior 4 trades show mixed outcomes: 2 of 4 prior buys were well-timed at the 90-day mark, though recent purchases on 2026-05-13 and 2026-05-12 posted only +2.2% and +0.5% 90-day returns respectively. Across all tickers, the insider's track record shows stronger execution (16 prior buys averaging +12.7% 30-day return, 75% 90-day win rate), but SLGL-specific timing has been inconsistent, warranting observation of whether this incremental purchase pattern continues or intensifies.

10% owner Opaleye Management adds 3,437 shares at SLGL, bringing stake to 488.4K shares amid -29.9% drawdown from 52-week high

Opaleye Management Inc, a 10% beneficial owner of Sol-Gel Technologies, purchased 3,437 shares totaling $231,502.33 on 2026-05-12, increasing its stake to 488,437 shares post-transaction. This accumulation occurs at a notably depressed valuation: the stock is trading at -29.9% from its 52-week high of $97.97 and down -10.2% over the prior 30 days, suggesting the insider is deploying capital into a weakness. The insider's historical track record shows 16 prior buys with an average 30-day return of +13.9% and a 90-day win rate of 100.00%, establishing a demonstrated pattern of bullish conviction on entry timing. Given Opaleye's substantial 10% ownership position and its track record of value-oriented purchases, this incremental buy into depressed prices warrants investor attention as a potential signal of conviction in Sol-Gel's recovery potential.

10% owner Opaleye Management buys 39,665 shares at $72.00 for $2,855,880.00

Opaleye Management executed 2 separate purchases totaling 39,665 shares for $2,855,880.00 at $72.00 per share on 2026-03-24. This transaction is notable because Opaleye is a 10% shareholder making a significant capital commitment ($2.9M) to increase its stake from a short position of -24,665 shares to a positive holding of 15,000 shares. Against current market price of $80.01, the buy occurred at an 10.0% discount to today's level, and the company's stock is down 4.7% over the past 30 days despite an 83.8% surge over 90 days. The insider's cross-ticker track record shows 16 prior buys against 4 prior sells, indicating a pattern of net accumulation across holdings. This multi-transaction filing represents a deliberate move to establish positive equity ownership.

10% owner Opaleye Management Inc. bought 291 shares of SLGL at $63.00 on 2026-02-13; stock now at $81.01, up 16.6% in 30 days.

Opaleye Management Inc., a 10% holder of Sol-Gel Technologies, purchased 291 shares at $63.00 on 2026-02-13, bringing its position to 450,335 shares. The stock has appreciated significantly since the transaction: it now trades at $81.01, representing a 16.6% gain over the past 30 days and a 126.6% gain over 90 days. This is the insider's fourth purchase within a 13-day window (buys on 2026-01-05, 2026-01-22, 2026-01-23, 2026-01-27, and 2026-02-02 preceded this transaction), suggesting sustained accumulation activity at SLGL. Across the insider's broader open-market history, 19 prior buys averaged +38.3% 30-day returns, establishing a pattern of buying into upward momentum. The timing of recent purchases—made as the stock was in an extended rally—reflects purchases made during a strong price advance rather than at depressed valuations.

10% owner Opaleye Management Inc. bought 100 shares of SLGL at $58.00 on 2026-02-02; stock up 49.2% in 30 days, 106.1% in 90 days.

Opaleye Management Inc., a 10% shareholder, purchased 100 shares at $58.00, adding modestly to holdings of 450.9K shares. The transaction itself is small relative to existing position (+0.0% vs pre-transaction holdings), yet occurs against a backdrop of rapid recent price appreciation: the stock has advanced 49.2% over 30 days and 106.1% over 90 days from the transaction date. The insider's cross-ticker track record shows 19 prior buys averaging +37.3% 30-day return, indicating a general pattern of favorable short-term entry timing across holdings. At the same ticker (SLGL), the insider has executed 5 trades in January–early February 2026; the two earliest measurable outcomes (January 2nd and 5th purchases) each posted +53% gains within 30 days, suggesting continued favorable positioning in this name. The current price of $65.95 sits 8.5% below the 52-week high of $72.10, providing near-peak entry context rather than a depressed valuation scenario.

10% owner Opaleye Management bought 100 shares of SLGL at $57.05 on 2026-01-27; stock up 43.3% in 30 days, +76.4% in 90 days.

Opaleye Management, a 10% shareholder, purchased 100 shares at $57.05, adding to a position now totaling 449,944 shares. This is the fifth buy at SLGL within a month (prior purchases on 2026-01-23, 2026-01-22, 2026-01-05, and 2026-12-31), signaling consistent accumulation. The stock has rallied 43.3% over 30 days and 76.4% over 90 days from the transaction date, and currently trades at $60.85, up significantly from the $4.10–$72.10 52-week range low but 15.6% below its 52-week high. The insider's cross-ticker track record shows 19 prior buys with an average 30-day return of +32.5%, though no prior buy outcomes are yet measurable at SLGL itself. The concentrated buying pattern and sustained price appreciation warrant monitoring of the company's fundamentals and any catalysts driving the rally.

10% owner Opaleye Management bought 3,324 shares at blended $56.36 over 2 days; 5 consecutive prior buys at SLGL in 5 days signals sustained accumulation.

Opaleye Management, a 10% owner of Sol-Gel Technologies, executed 2 purchases totaling 3,324 shares for $187,356.50 on January 22–23, 2026, at a blended average price of $56.36. This filing follows 5 consecutive prior buys at SLGL spanning December 29, 2025 through January 5, 2026—a pattern of sustained open-market accumulation within a narrow 7-calendar-day window. The current price of $58.44 sits 19.0% below the 52-week high of $72.10, and the stock has advanced 34.2% over the preceding 30 days and 49.8% over 90 days. Across Opaleye's broader cross-ticker trading history, 17 prior open-market buys averaged a 30-day return of +28.9%, though timing outcomes at SLGL remain unmeasurable for all 5 same-ticker trades. The repeated open-market purchases by a principal shareholder during a period of price strength warrants attention to underlying company dynamics and the catalyst driving this accumulation pattern.