SEPN Septerna, Inc. Insider Trading

Chief People Officer Samira Shaikhly sells 70,453 shares (70.5K) for $1,979,838.27, retaining only 793 shares post-transaction.

Shaikhly Samira, Chief People Officer at Septerna, executed 2 separate sales totaling 70,453 shares for $1,979,838.27 at blended average price of $28.10 on 2026-03-02. This represents a near-complete liquidation of her position, reducing her holdings by 98.9% from 71,246 shares to 793 shares retained. The company's fundamentals are mixed: revenue grew 611.9% year-over-year ($21.5M latest quarter) and the most recent quarter was profitable ($8.2M net income), but the full fiscal year remained unprofitable. The stock is currently priced at $28.82, within 6.6% of its 52-week high and up 15.1% over the past 30 days. Near-complete insider liquidation by a senior executive warrants examination of whether other leadership changes, strategic concerns, or organizational shifts may be underway.

Director Ezekowitz buys 13,319 shares of SEPN at $6.93 amid 74.5% 90-day decline; 3 other insiders bought in past 14 days

Director Alan Ezekowitz purchased 13,319 shares at $6.93 on 2025-03-07, increasing his holdings by 12.8% to 117,420 shares. This transaction is part of a broader cluster pattern in which 3 other insiders also bought within the past 14 days, suggesting coordinated interest at current valuations. The purchase occurred after the stock declined 74.5% over 90 days and 55.2% over 30 days, with shares trading 78.3% below the 52-week high of $27.09. Septerna's most recent quarterly results show net income of $-20,523,000.00 against revenue of $176,000.00, indicating significant operating losses; context on timing, strategic rationale, or any non-public information that may have motivated the cluster buy requires deeper analysis.

CEO Finer Jeffrey bought 17,000 shares at $5.68-$5.80 across 3 transactions; cluster pattern with 2 other insiders buying within 14 days as stock down 78.6% from 52-week high.

CEO and President Finer Jeffrey executed 3 separate purchases totaling 17,000 shares for $96,960.60 over three consecutive trading days (Feb 25–27), expanding his holdings from 754,907 to 771,907 shares. This buying activity occurs amid severe stock deterioration: the stock is down 78.6% from its 52-week high of $27.09 and down 63.8% over the past 30 days, yet the CEO continues to accumulate at prices ranging from $5.68 to $5.80. A cluster pattern is present, with 2 other insiders also buying within the past 14 days, indicating coordinated insider accumulation. The fundamental backdrop shows the company generated only $176,000.00 in latest-quarter revenue against a net loss of $-20,523,000.00, creating a material disconnect between the company's cash burn and the timing of these insider purchases.

CFO Labrucherie buys 10,000 shares for $56,866.68 at blended $5.69; stock down 78.6% from $27.09 high, cluster buy underway.

Labrucherie Gil M, Chief Financial Officer at Septerna, Inc., executed 2 separate purchases totaling 10,000 shares (10.0K shares) for $56,866.68 at a blended average price of $5.69 on 2025-02-25 and 2025-02-27, increasing holdings from 30,000 to 40,000 shares. This $56.9K commitment is contextually significant given the stock's 78.6% decline from its 52-week high of $27.09 and 77.1% decline over 90 days. The transaction is part of a cluster pattern, with 2 other insiders also buying within the past 14 days, suggesting coordinated conviction at current levels. However, the company's latest quarter shows $176,000.00 in revenue against a net income loss of $20,523,000.00, presenting fundamental headwinds that warrant scrutiny. Investor attention should focus on whether this insider accumulation reflects information asymmetry about operational recovery or is merely a tactical trade in a financially distressed entity.

Third Rock Ventures VI (10% owner) buys 18,861 shares of SEPN at $6.00 on 2025-02-24; cluster pattern with 2 other insiders buying within 14 days amid -79.0% decline from 52-week high.

Third Rock Ventures VI purchased 18,861 shares at $6.00, increasing holdings to 4,211,659 shares (+0.4% vs pre-transaction). This buy arrives during severe price erosion: the stock is -79.0% from its 52-week high of $27.09, -64.7% over 30 days, and -77.0% over 90 days, with current price at $5.70. The transaction is part of a cluster pattern in which 2 other insiders also bought within the past 14 days, including two prior purchases by this same entity on 2025-02-20 and 2025-02-21. Fundamentals remain weak, with the latest quarterly revenue at $176,000.00 and net income at -$20,523,000.00. The timing and clustering of purchases during a steep drawdown warrant examination, though the outcomes of the prior same-ticker trades on 2025-02-20 and 2025-02-21 are not yet measurable.

Third Rock Ventures VI acquired 1,040,342 shares at blended $5.93 (Feb 20–21), expanding stake to 4.19M shares (+33.0%); stock down -78.8% from 52-week high.

Third Rock Ventures VI, a 10% owner, made 2 separate purchases totaling 1,040,342 shares for $6,167,378.00 at a blended average price of $5.93, increasing its holdings by 33.0% to 4,192,798 shares post-transaction. The stock currently trades at $5.73, down -78.8% from its 52-week high of $27.09 and -69.0% over the past 30 days. The timing and scale of this accumulation—executed during a severe drawdown—warrant scrutiny given the company's fundamental challenges: latest quarterly revenue of $176,000.00 against a net loss of $-20,523,000.00. The insider's one prior measurable buy at this ticker is not yet yielding outcome data, and the cross-ticker track record shows only 1 historical buy, leaving no pattern to evaluate timing acumen at this issuer or broadly.

CFO Labrucherie purchases 30,000 shares across 3 days at $5.74 blended avg; stock down 78.6% from 52-week high.

Labrucherie Gil M, Chief Financial Officer, executed 3 separate purchases totaling 30,000 shares for $172,296.90 between February 19–21, 2025, at a blended average price of $5.74. The current price of $5.80 places this near his entry cost, yet the stock is -78.6% from its 52-week high of $27.09, and the 90-day decline stands at -73.6%. The company's latest quarterly revenue of $176,000.00 and net loss of $-20,523,000.00 indicate severe operational stress. The CFO's accumulation of a material position (30.0K shares, a new holding from zero) during a steep drawdown warrants investor attention to both his confidence assessment and the underlying business trajectory.

RA Capital Management (director) buys 4,170,000 shares at $18.00 for $75,060,000 across 2 transactions on 2024-10-28, 4 days post-IPO.

RA Capital Management, a venture investor and board member, acquired 4,170,000 shares through 2 separate purchases at $18.00 per share totaling $75,060,000 during Septerna's first week of public trading (4 trading days post-IPO). The transaction reflects substantial capital commitment from a director at the IPO reference price, establishing a significant director position during the critical early-trading window. Given the recent listing status and the material size of this purchase relative to what appears to be controlled or affiliated share issuance, investors should monitor whether this represents director confidence at the IPO price or part of a structured capital-raise backstop agreement common to early-stage biotech IPOs.

Third Rock Ventures V acquires 650,000 SEPN shares for $11,700,000 in 2 purchases at $18.00; post-transaction holdings reach 3,152,456 shares

Third Rock Ventures V, a 10% owner, executed 2 separate purchases totaling 650,000 shares for $11,700,000 at $18.00 on 2024-10-28, increasing holdings by 26.0% from 2,502,456 to 3,152,456 shares. The purchase occurred at $18.00 while current price stands at $20.75—a 15.3% premium to the transaction price. This transaction occurs in early stages of the company's public life (RECENT LISTING with only 2 trading days of history), where 52-week metrics are not yet meaningful. The substantial size ($11.7M) and staged execution across two transactions suggests deliberate accumulation by a significant existing stakeholder, though the actual basis for this decision cannot be determined from filing data alone.