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INSM INSMED Inc Insider Trading

Latest: Chair and CEO Sold $1.5M of Shares · May 2026

Multiple insiders have been active at INSMED Inc (INSM): 10 distinct insiders account for 1 buy filing and 78 sell filings as of Jul 2026. Its highest-significance filing in the last 90 days: Chair and CEO Lewis William sold $1.5M, transaction dated May 2026.

79 filings analyzed · Latest 2026-07-10

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Buys
1
Sells
78
Insiders
10
Direction
Net selling

INSMED Inc leadership

CEO
William H. Lewis Chief Executive Officer Of Insmed Incorporated — Chief Executive Officer
CFO
Sara Bonstein Chief Financial Officer Of Insmed Incorporated — Chief Financial Officer
COO
Roger Adsett — Chief Operating Officer
General Counsel
Michael A. Smith — Chief Legal Officer
Chair
William H. Lewis — Chair and Chief Executive Officer

Historically, stocks have lagged the S&P 500 by a median ~3% over the 90 days after a medium insider sell (n ≈ 4,738, 2024-2026). Past results don't predict the future. How we measure this ↗

July 2026
2026-07-10 10b5-1 Plan
medium
Chair and CEO
10,699 shares
$1,256,084
@ $117.40
Significance 5

William Lewis sells 10,699 shares at avg $117.40 under 10b5-1 plan; holds 259,058 shares plus 10,700 in options

William Lewis, Chair and CEO, executed 3 separate sales totaling 10,699 shares for $1,256,084.13 on 2026-07-09 at prices ranging from $116.55 to $118.52, all conducted under a pre-arranged 10b5-1 trading plan adopted on 2025-09-04. The sale represents a 4.0% reduction from his pre-transaction holdings of 269,757 shares, leaving him with 259,058 non-derivative shares post-trade plus 10,700 shares remaining in stock option holdings. The stock currently trades at $115.61, within 52 weeks of a $212.75 peak and down 25.3% over the past 90 days, though up 25.8% in the past 30 days. His cross-ticker track record across 20 prior sales shows an average 90-day return of -31.0%, though those outcomes are not directly predictive of this ticker where five prior scheduled sales occurred on 2026-06-25. The company reported $306.0M in quarterly revenue with 66.7% annual growth but net losses of $163.6M in the latest quarter, reflecting continued unprofitability despite strong top-line expansion.

2026-07-08 10b5-1 Plan
medium
Chief Medical Officer
12,302 shares
$1,352,932
@ $109.98
Significance 5

INSM CMO Flammer sells 12,302 shares for $1,352,931.88 under pre-arranged 10b5-1 plan

Martina M.D. Flammer, Chief Medical Officer of INSMED Inc (INSM), executed 2 separate sales totaling 12,302 shares for $1,352,931.88 on 2026-07-06 at a blended average price of $109.98, representing a 16.9% reduction in her non-derivative holdings to 60,486 shares. This transaction was executed under a pre-arranged 10b5-1 trading plan adopted on 2025-02-27, meaning the sale was scheduled and non-discretionary. The stock currently trades at $116.53, 45.2% below its 52-week high, and Flammer retains substantial derivative holdings (28,193 shares in stock options), indicating her ongoing exposure to the company. Her prior open-market sells across all tickers have averaged -10.2% return over 30 days and -9.1% over 90 days, while her 5 recent same-ticker sales at INSM (all in May 2026) showed negative 30-day returns ranging from -8.4% to -16.8%.

June 2026
2026-06-26 10b5-1 Plan
medium
Chair and CEO
21,398 shares
$2,210,763
@ $103.32
Significance 6

INSM CEO Lewis sells 21,398 shares for $2,210,762.94 via scheduled 10b5-1 plan; stock -51.4% from 52-week high

William Lewis, Chair and CEO of INSMED Inc, executed five separate sales totaling 21,398 shares for $2,210,762.94 on 2026-06-25 under a pre-arranged 10b5-1 trading plan adopted on 2025-09-04, reducing his non-derivative holdings to 258,917 shares. The stock has declined -51.4% from its 52-week high of $212.75 and is down -28.8% over 90 days, while the company reported a net loss of $163,563,000.00 in its latest quarter despite annual revenue growth of +66.7%. Across his prior five trades at INSM dating back to 2026-05-18, Lewis's sales have been followed by 30-day declines ranging from -6.5% to -8.0%, and his cross-ticker track record shows an average 90-day return of -31.4% after 20 prior sells, indicating a pattern of sales preceding further weakness. However, this transaction is governed by a scheduled 10b5-1 plan rather than discretionary timing, and Lewis retains 21,399 shares in stock option holdings, preserving meaningful derivative exposure to the company's upside.

2026-06-10 10b5-1 Plan
medium
Chair and CEO
6,515 shares
$612,605
@ $94.03
Significance 4

Chair/CEO William Lewis sells 6,515 shares of INSM at $94.03 under pre-arranged 10b5-1 plan; stock down 56.8% from 52-week high.

William Lewis sold 6,515 shares of INSMED Inc (INSM) on 2026-06-08 at $94.03, reducing his holdings by -2.5% to 258,917 shares. This transaction is part of a pre-arranged 10b5-1 trading plan adopted on 2025-09-04, meaning it was scheduled rather than discretionary. The stock has declined -11.6% over the past 30 days and -34.2% over the past 90 days, trading -56.8% below its 52-week high of $212.75. INSMED remains unprofitable with net income of $-163.6M despite strong annual revenue growth of +66.7%, generating $306.0M in latest quarterly revenue. Across his prior five sales at INSM, post-trade returns have ranged from -24.2% to -0.4% over 90-day windows, whereas his cross-ticker track record shows an average 90-day return of -22.5% following sales. The scheduled nature of this sale prevents timing-based interpretation; investors should monitor how the stock's recent steep decline and ongoing unprofitability trajectory align with company fundamentals and market conditions.

May 2026
2026-05-22 10b5-1 Plan
low
Chief Legal Officer
6,149 shares
$666,982
@ $108.47
Significance 3

CLO Michael Alexander Smith sold 6,149 shares of INSM at $108.47; stock now at $106.24, down 50.1% from 52-week high.

Michael Alexander Smith, Chief Legal Officer, sold 6,149 shares (reducing holdings from 47,762 to 41,613 shares) under a pre-arranged 10b5-1 trading plan adopted on 2025-11-07, making this a scheduled, non-discretionary transaction. The sale occurred at $108.47 per share for total value of $666,982.03, while the company's current stock price stands at $106.24 within a 52-week range of $64.84–$212.75. INSMED remains unprofitable with net income of -$163,563,000.00 on quarterly revenue of $305,964,000.00, despite annual revenue growth of 66.7%. The broader context shows the stock has declined 50.1% from its 52-week high and 26.5% over the prior 30 days.

2026-05-20 10b5-1 Plan
medium
Chair and CEO
25,564 shares
$2,718,224
@ $106.33
Significance 5

INSM Chair/CEO Lewis William sold 25,564 shares for $2.7M via scheduled 10b5-1 plan; stock down -49.3% from 52-week high

Lewis William executed 3 separate sales totaling 25,564 shares for $2,718,223.75 on 2026-05-18 under a pre-arranged 10b5-1 trading plan adopted 2025-09-04, reducing his holdings by 8.6%. The company is unprofitable ($-163.6M net income in latest full fiscal year) despite strong revenue growth (+66.7% annually) and a substantial $23.4B market cap. The stock has declined -24.4% over 30 days and -33.0% over 90 days, trading -49.3% below its 52-week high of $212.75. Because this transaction is scheduled under a 10b5-1 plan rather than discretionary, the timing reflects pre-established parameters rather than current market judgment. Lewis William's prior 5 sales at INSM (all on 2026-05-04) were followed by declines ranging from -14.5% to -17.2% over both 30- and 90-day periods, consistent with his broader cross-ticker track record showing an average 90-day return of -20.1% after his 20 prior sales.

2026-05-15 10b5-1 Plan
medium
Chief Medical Officer
18,333 shares
$2,128,892
@ $116.12
Significance 4

CMO Martina M.D. Flammer sells 10,479 shares at $117.54 via 10b5-1 plan; stock down 48.7% from 52-week high

Flammer, Chief Medical Officer, sold 10,479 shares (10.5K shares) on 2026-05-14 at $117.54 pursuant to a pre-arranged 10b5-1 trading plan adopted on 2025-02-27, reducing her holdings by 13.9% to 64,910 shares. The stock has declined 48.7% from its 52-week high of $212.75 and is down 25.6% over the past 30 days. Because this sale is scheduled under a 10b5-1 plan rather than discretionary, the transaction timing reflects a pre-determined schedule set nearly three months before execution, not an ad hoc decision responding to current market conditions. INSM remains unprofitable with net income of $-163.6M against latest-quarter revenue of $306.0M, though the company posted 66.7% annual revenue growth, indicating growth remains decoupled from profitability. At INSM specifically, Flammer's two prior sales in early May both posted positive 30-day and 90-day returns, while her three prior sales in February posted negative returns, showing mixed historical outcomes at this ticker and no clear pattern that would distinguish this 10b5-1 disposition as strategically timed.

2026-05-13 10b5-1 Plan
medium
Chief Medical Officer
12,949 shares
$1,300,121
@ $100.40
Significance 6

CMO Flammer executes exercise-and-sell: 12,949 shares acquired and nearly all shares sold same-day at steep markup, realizing ~$1.3M proceeds.

Dr. Martina Flammer, Chief Medical Officer of Insmed, exercised 12,949 shares and then immediately sold 12,949 shares on the same day—a pattern that completely offsets her equity gain and locks in liquidity. The sale price significantly exceeded her exercise price, translating to approximately $1.3 million in total disposition proceeds. This represents her sixth and seventh open-market sales at Insmed over the past three years, as her trading activity has been exclusively selling (zero open-market purchases). Notably, all five of her prior sales at this company showed the stock declining afterward—a pattern of uniformly well-timed exits that suggests Flammer has consistently exited before downturns. The stock currently trades well below its 52-week high and has declined materially over the past month and quarter, while the company remains unprofitable despite strong revenue growth. The exercise-and-sell structure combined with her consistent exit timing suggests a pattern of disciplined liquidity management rather than a vote of confidence in the company's near-term direction.

2026-05-06 10b5-1 Plan
medium
Chair and CEO
10,699 shares
$1,469,442
@ $137.34
Significance 7

INSM Chair & CEO Lewis William exercises options and sells 10,699 shares in net-neutral transaction, extending a consistent sell pattern at this ticker.

Lewis William, Chair and CEO of Insmed, executed a classic exercise-and-sell transaction — acquiring shares through two option exercises and immediately disposing of the same number of shares on the open market, leaving his net holdings unchanged. This filing represents his sixth through eleventh open-market sales at INSMED in the three-year window, continuing a pattern of consistent selling at this company. What makes this worth watching is his prior track record: across all five of his previous open-market sales at INSMED with measurable outcomes, the stock declined afterward in both the near term and over a longer horizon — meaning every prior exit proved well-timed at both the 30-day and 90-day mark. He executed the current sales while Insmed's stock trades well below its 52-week high and has declined significantly over both the past month and the prior three months. On the fundamentals side, the company is not yet profitable, though it has posted strong revenue growth year-over-year, which creates a mixed backdrop. The persistent sell pattern from the company's top executive, combined with a historically accurate exit record, makes this filing more notable than a typical exercise-and-sell would otherwise suggest.

April 2026
2026-04-17 10b5-1 Plan
medium
Chair and CEO
10,699 shares
$1,540,332
@ $143.97
Significance 6

Chair/CEO Lewis William sells 10,699 shares in 4 separate transactions for $1,540,331.72; post-transaction holdings 301,185 shares

Lewis William, Chair and CEO of INSMED, executed 4 separate open-market sales on 2026-04-16 totaling 10,699 shares for $1,540,331.72, reducing his holdings by 3.4% to 301,185 shares. The transaction prices ranged from $142.99 to $145.79, clustering near the current price of $144.48. This sale occurs amid significant company volatility: INSM is down 31.7% from its 52-week high of $211.41, though the stock is up 1.2% over the prior 30 days. The company is currently unprofitable (net income of $-370.0M in the latest quarter) despite strong revenue growth of 66.7% year-over-year. Prior to this filing, Lewis William executed three separate sell transactions at INSM on 2026-04-06 and 2026-03-19, indicating active share reduction over recent weeks. His cross-ticker track record shows 20 prior sales with an average 30-day return of -1.3%, though timing outcomes at INSM specifically remain not yet measurable.

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